Regulate
The foundation of restoration.
Restore physiology, hormones, metabolism, inflammation, and foundational health.
BY APPLICATION · EST. 2021
Beyond symptom management. Toward true restoration.
A private institute integrating advanced medicine, longevity science, hormonal optimization, aesthetic restoration, and multidimensional health — so each patient may become the fullest expression of themselves.
Led by Ashlee Zeighami, APRN, FNP-C · McKinney, Texas
Manifesto
We believe medicine, at its best, is intimate. That a single hour of unhurried attention is worth more than a dozen prescriptions. And that beauty, vitality, and longevity are not luxuries — they are the natural expression of a body in alignment.
— The House of Serenya
The Serenya Difference
Most medicine asks: “What symptoms do you have?”
We ask: “What is your body trying to communicate?”
We do not view symptoms in isolation. We listen for the deeper pattern — the signal beneath the symptom — and address the root cause with precision, patience, and care.
The Serenya MethodThree movements of
Three movements of
quiet, deliberate care.
Our method is neither rushed nor reduced. It unfolds in three movements — each designed to return the practice of medicine to its most considered form.
Recalibrate
The return to coherence.
Restore nervous system regulation, emotional resilience, adaptive beliefs, and the deeper influences on wellbeing.
Ascend
The fullest expression of health and human potential.
Cultivate vitality, longevity, purpose, embodied wellbeing and self-mastery.
Each patient's path is unique. Our role is to discern where restoration begins— and guide the journey toward transformation.
Plate I.Portrait of the Founder
The Founder
Ashlee Zeighami.
After more than a decade in high-acuity clinical practice, Ashlee came to believe that many patients were not lacking treatment— they were lacking time, attention, and a deeper investigation into why symptoms had developed in the first place.
Serenya Institute was created from the conviction that medicine should be personal, comprehensive, and transformative. By integrating advanced clinical medicine, longevity science, regenerative aesthetics, and root-cause investigation, Ashlee created a practice designed around the person, not merely the diagnosis.
A board-certified Family Nurse Practitioner, Ashlee brings more than a decade of experience across primary care, hormone optimization, longevity medicine, peptide therapy, weight-loss management, and regenerative aesthetics. Her work is guided by the belief that health is not merely the absence of disease, but the restoration of coherence across every dimension of wellbeing.
“I built Serenya for the patient I would want to be — one who is never rushed, never reduced, and always feels seen.”
PRIVATE MEMBERSHIP
Request an InvitationBegin your application.
A limited number of members are accepted each year to preserve the depth of care that defines the Serenya experience. Each application is read personally by Ashlee.
The Journal
All letters Letters from Serenya.
Where medicine meets meaning. Quiet dispatches on restoration, longevity, and multidimensional health.
Longevity · April 2026
What Is a Longevity Clinic?
A clear definition of the modern longevity clinic — and how it differs from functional medicine, concierge primary care, and the reactive model most of us inherited.
Hormones · March 2026The Quiet Discipline of Hormonal Care
Why bioidentical protocols, when written by hand, remain the most intimate form of medicine.
Longevity · February 2026Longevity as a Slow Art
Peptides, biomarkers, and the unhurried patience required to read a life across decades.